(Rac)-SHIN2 is a pyrazolopyran derivative that functions as a selective inhibitor of serine hydroxymethyltransferase (SHMT). This compound demonstrates significant antibacterial activity, effectively targeting both vancomycin-susceptible and vanA-type vancomycin-resistant Enterococcus, while exhibiting low cytotoxicity towards Hep2 cells. The potential applications of (Rac)-SHIN2 include investigation into bacterial resistance mechanisms and the development of novel antibacterial therapeutics.
(Rac)-SHIN2 is a pyrazolopyran derivative that functions as a selective inhibitor of serine hydroxymethyltransferase (SHMT). This compound demonstrates significant antibacterial activity, effectively targeting both vancomycin-susceptible and vanA-type vancomycin-resistant Enterococcus, while exhibiting low cytotoxicity towards Hep2 cells. The potential applications of (Rac)-SHIN2 include investigation into bacterial resistance mechanisms and the development of novel antibacterial therapeutics.
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