RAF-IN-1 is a potent inhibitor of b/cRAF, demonstrating IC50 values of 3.8 nM for cRAF, 36 nM for bRAF wild-type, and 29.4 nM for the bRAFV600E mutant. This compound effectively inhibits cell growth in cancer cell lines harboring the bRAFV600E mutation, with GI50 values of 3.4 nM in H358 and 2.9 nM in A375 cells. RAF-IN-1 is valuable for research in cancer biology, particularly in studies targeting the RAS-RAF-MEK-ERK signaling pathway.
RAF-IN-1 is a potent inhibitor of b/cRAF, demonstrating IC50 values of 3.8 nM for cRAF, 36 nM for bRAF wild-type, and 29.4 nM for the bRAFV600E mutant. This compound effectively inhibits cell growth in cancer cell lines harboring the bRAFV600E mutation, with GI50 values of 3.4 nM in H358 and 2.9 nM in A375 cells. RAF-IN-1 is valuable for research in cancer biology, particularly in studies targeting the RAS-RAF-MEK-ERK signaling pathway.
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