RAF265 (CHIR-265)

Name: RAF265 (CHIR-265)
Brand: Adooq Bioscience
SKU: A10773
Rating: 100 (268 reviews)

Catalog No.: A10773

RAF/VEGFR Inhibitor

RAF265 (CHIR-265) Chemical Structure

CAS NO. 927880-90-8

RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers.

Availability: In stock

Package	Price	Qty
5 mg	$95.00
10 mg	$162.00
25 mg	$285.00
50 mg	$475.00
10mM * 1mL in DMSO	$183.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

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Biological Activity

RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers.

Targets

VEGFR2 (Cell-free assay)	B-Raf (Cell-free assay)
30 nM(EC50)	3 nM-60 nM

Solubility *

In vitro (25°C)	DMSO	85 mg/mL (163.96 mM)
	Water	Insoluble
	Ethanol	28 mg/mL (54.01 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.29 mL	96.45 mL	192.9 mL
0.5 mM	3.86 mL	19.29 mL	38.58 mL
1 mM	1.93 mL	9.65 mL	19.29 mL
5 mM	0.39 mL	1.93 mL	3.86 mL

*The above data is based on the productmolecular weight 518.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10773
Actions	Inhibitor
CAS No.	927880-90-8
Formula	C24H16F6N6O
M. Wt	518.4
Purity	>98%
SMILES	CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.