RAF265 (CHIR-265)

Catalog No.: A10773

RAF/VEGFR Inhibitor

RAF265 (CHIR-265) Chemical Structure

CAS NO. 927880-90-8

RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $120.00

Special Price $96.00

10 mg

Regular Price: $200.00

Special Price $160.00

25 mg

Regular Price: $380.00

Special Price $304.00

50 mg

Regular Price: $650.00

Special Price $520.00

10mM * 1mL in DMSO
$183.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers.
Targets
VEGFR2 (Cell-free assay) B-Raf (Cell-free assay)
30 nM(EC50)3 nM-60 nM
In vitro (25°C) DMSO 100 mg/mL (192.89 mM)
Water <1 mg/mL (<1 mM)
Ethanol 33 mg/mL (63.65 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.29 mL 96.45 mL 192.9 mL
0.5 mM 3.86 mL 19.29 mL 38.58 mL
1 mM 1.93 mL 9.65 mL 19.29 mL
5 mM 0.39 mL 1.93 mL 3.86 mL

*The above data is based on the productmolecular weight 518.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10773
Actions Inhibitor
M. Wt 518.4
Formula C24H16F6N6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 927880-90-8
SMILES CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F

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