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Raltitrexed (Tomudex)

Catalog No.: A10776

DNA/RNA Synthesis inhibitor

Raltitrexed (Tomudex)

Raltitrexed (Tomudex) Chemical Structure

CAS NO. 112887-68-0

Raltitrexed (Tomudex) is an inhibitor of thymidylate synthase and also is one of the strongest antimetabolites in use.

Availability: In stock

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10mM * 1mL in DMSO
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  • Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7

Biological Activity

Raltitrexed (Tomudex) is an inhibitor of thymidylate synthase and also is one of the strongest antimetabolites in use.
In vitro DMSO 83 mg/mL (181.02 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.81 mL 109.05 mL 218.1 mL
0.5 mM 4.36 mL 21.81 mL 43.62 mL
1 mM 2.18 mL 10.91 mL 21.81 mL
5 mM 0.44 mL 2.18 mL 4.36 mL

*The above data is based on the productmolecular weight 458.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10776
Actions Inhibitor
CAS No. 112887-68-0
Formula C21H22N4O6S
M. Wt 458.5
Purity >98%
Synonyms Tomudex, TDX, ZD 1694
SMILES CC1=NC(=O)C2=C(N1)C=CC(=C2)CN(C)C3=CC=C(S3)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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