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- Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7
Biological Activity
Raltitrexed (Tomudex) is an inhibitor of thymidylate synthase and also is one of the strongest antimetabolites in use.
Targets
| In vitro | DMSO | 83 mg/mL (181.02 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.81 mL | 109.05 mL | 218.1 mL |
| 0.5 mM | 4.36 mL | 21.81 mL | 43.62 mL |
| 1 mM | 2.18 mL | 10.91 mL | 21.81 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.36 mL |
*The above data is based on the productmolecular weight 458.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10776 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 112887-68-0 |
| Formula | C21H22N4O6S |
| M. Wt | 458.5 |
| Purity | >98% |
| Synonyms | Tomudex, TDX, ZD 1694 |
| SMILES | CC1=NC(=O)C2=C(N1)C=CC(=C2)CN(C)C3=CC=C(S3)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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