Ramelteon-d5 is a deuterated form of Ramelteon, a highly selective and potent agonist of the MT1 and MT2 melatonin receptors, exhibiting Ki values of 14 pM and 112 pM, respectively. This stable isotope is valuable for research studies focusing on insomnia and sleep disorders, as Ramelteon has demonstrated efficacy in reducing sleep onset during long-term treatment without leading to next-morning residual effects or withdrawal symptoms upon discontinuation. Researchers can utilize Ramelteon-d5 in pharmacokinetic and metabolic studies to gain insights into the compound's mechanism and therapeutic potential.
Ramelteon-d5 is a deuterated form of Ramelteon, a highly selective and potent agonist of the MT1 and MT2 melatonin receptors, exhibiting Ki values of 14 pM and 112 pM, respectively. This stable isotope is valuable for research studies focusing on insomnia and sleep disorders, as Ramelteon has demonstrated efficacy in reducing sleep onset during long-term treatment without leading to next-morning residual effects or withdrawal symptoms upon discontinuation. Researchers can utilize Ramelteon-d5 in pharmacokinetic and metabolic studies to gain insights into the compound's mechanism and therapeutic potential.
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