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|Storage||at -20°C 3 years Powder|
|Synonyms||Rozerem, TAK-375, TAK375|
|SMILES code||CCC(=O)NCC[[email protected]@H]1CCC2=C1C3=C(C=C2)OCC3|
|Chemical Name||(S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b] furan-8-yl)ethyl]propionamide|
|Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ± 8.55 pM)and MT2 (20.1 ± 9.25 pM)receptors and selectivity over the MT3 receptor.|
|Solubility (25°C) *||In vitro||DMSO||52 mg/mL (200.5 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||52 mg/mL (200.5 mM)|
|In vivo||0.5% methylcellulose||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||38.57 mL||192.83 mL||385.65mL|
|0.5 mM||7.71 mL||38.57 mL||77.13 mL|
|1 mM||3.86 mL||19.28 mL||38.57 mL|
|5 mM||0.77 mL||3.86 mL||7.71 mL|
*The above data is based on the productmolecular weight 259.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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