Ramelteon (TAK-375)

Catalog No.: A10777

MT1/MT2-Receptor Agonist

Ramelteon (TAK-375) Chemical Structure

CAS NO. 196597-26-9

Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ± 8.55 pM)and MT2 (20.1 ± 9.25 pM)receptors and selectivity over the MT3 receptor.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$120.00
25 mg
$200.00
50 mg
$260.00
10mM * 1mL in DMSO
$106.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ± 8.55 pM)and MT2 (20.1 ± 9.25 pM)receptors and selectivity over the MT3 receptor.
Targets
MT1 receptor MT receptor (chicken) MT2 receptor
14 pM(Ki)23.1 pM(Ki)112 pM(Ki)
In vitro (25°C) DMSO 52 mg/mL (200.5 mM)
Water <1 mg/mL (<1 mM)
Ethanol 52 mg/mL (200.5 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.57 mL 192.83 mL 385.65 mL
0.5 mM 7.71 mL 38.57 mL 77.13 mL
1 mM 3.86 mL 19.28 mL 38.57 mL
5 mM 0.77 mL 3.86 mL 7.71 mL

*The above data is based on the productmolecular weight 259.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10777
Actions Agonist
M. Wt 259.3
Formula C16H21NO2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 196597-26-9
Synonyms Rozerem, TAK-375, TAK375
SMILES CCC(=O)NCC[[email protected]@H]1CCC2=C1C3=C(C=C2)OCC3

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