Rapamycin (Sirolimus)

Catalog No.: A10782

mTOR Inhibitors

Rapamycin (Sirolimus)

Rapamycin (Sirolimus) Chemical Structure

CAS NO. 53123-88-9

Rapamycin (Sirolimus) prevents activation of T cells and B-cells by inhibiting their response to interleukin-2 (IL-2).

Availability: In stock

Package Price Qty
5 mg
$40.00
50 mg
$55.00
100 mg
$70.00
10mM * 1mL in DMSO
$50.00
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  • Ashley VanCleave, .et al. Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway, Oncotarget, 2020, Jul 7; 11(27): 2597-2610 PMID: 32676162
  • Y Huang, .et al. STIM1 controls calcineurin/Akt/mTOR/NFATC2?mediated osteoclastogenesis induced by RANKL/M?CSF, Experimental and Therapeutic Medicine, 2020, 20(2), 736-747
  • Takuya Hirao, .et al. Altered intracellular signaling by imatinib increases the anti‐cancer effects of tyrosine kinase inhibitors in chronic myelogenous leukemia cells, Cancer Sci, 2018, Jan; 109(1): 121-131 PMID: 29121435
  • Ya-Hui Chen, .et al. The Different Effects of Atorvastatin and Pravastatin on Cell Death and PARP Activity in Pancreatic NIT-1 Cells, J Diabetes Res, 2016, 2016: 1828071 PMID: 28004006
  • >

Biological Activity

Rapamycin (Sirolimus) prevents activation of T cells and B-cells by inhibiting their response to interleukin-2 (IL-2).
Targets
mTOR (HEK293 cells)
~0.1 nM
In vitro (25°C) DMSO 20 mg/mL (21.87 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC/0.25% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.94 mL 54.69 mL 109.39 mL
0.5 mM 2.19 mL 10.94 mL 21.88 mL
1 mM 1.09 mL 5.47 mL 10.94 mL
5 mM 0.22 mL 1.09 mL 2.19 mL

*The above data is based on the productmolecular weight 914.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10782
Actions Inhibitor
M. Wt 914.2
Formula C51H79NO13
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 53123-88-9
Synonyms Rapamune
SMILES C[[email protected]@H]1CC[[email protected]]2C[[email protected]@H](/C(=C/C=C/C=C/[[email protected]](C[[email protected]](C(=O)[[email protected]@H]([[email protected]@H](/C(=C/[[email protected]](C(=O)C[[email protected]](OC(=O)[[email protected]@H]3CCCCN3C(=O)C(=O)[[email protected]@]1(O2)O)[[email protected]](C)C[[email protected]@H]4CC[[email protected]]([[email protected]@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC

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