Fig. 1 · Structure
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Regorafénib N-oxyde-d3(M2)
Stable Isotope
Regorafénib N-oxyde-d3(M2) is a deuterium-labeled analog of Regorafénib N-oxyde M2, an active metabolite of the multi-targeted inhibitor Regorafenib. This compound targets key receptors including VEGFR1/2/3, PDGFRβ, Kit, RET, and Raf-1, exhibiting IC50 values of 13, 4.2, 46, 22, 7, 1.5, and 2.5 nM, respectively. Regorafénib N-oxyde-d3(M2) is primarily utilized in stable isotope labeling studies to trace metabolic pathways and explore pharmacokinetics in research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1333489-03-4 |
| Applications | Stable Isotope |
| Formula | C21H12D3ClF4N4O4 |
| Molecular Weight | 501.83 |
| SMILES | [2H]C([2H])([2H])NC(C1=CC(OC2=CC(F)=C(C=C2)NC(NC3=CC(C(F)(F)F)=C(C=C3)Cl)=O)=CC=[N+]1[O-])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.