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RFRP-1(human)

Catalog No.: A62203
NPFF Receptor Agonist
RFRP-1 (human) is a potent Neuropeptide FF (NPFF) receptor agonist that targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes, effectively inhibiting gonadotropin release. This compound demonstrates high affinity for the NPFF receptors, with EC50 values of 0.0011 nM for NPFF2 and 29 nM for NPFF1. RFRP-1 (human) is valuable in research applications related to hormonal regulation and neuroendocrine signaling.
RFRP-1(human) 311309-25-8 NPFF Receptor Agonist
Grouped product items
Size Price Stock Qty
1mg
$60.00
In stock
5mg
$150.00
In stock
10mg
$225.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRFRP-1 (human) is a potent Neuropeptide FF (NPFF) receptor agonist that targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes, effectively inhibiting gonadotropin release. This compound demonstrates high affinity for the NPFF receptors, with EC50 values of 0.0011 nM for NPFF2 and 29 nM for NPFF1. RFRP-1 (human) is valuable in research applications related to hormonal regulation and neuroendocrine signaling.
Product Information
Catalog NumA62203
FormulaC67H101N19O14S
Molecular Weight1428.70
CAS Number311309-25-8
Sequence shorteningMPHSFANLPLRF-NH2
SMILESC(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N)=O)=O)CCCNC(=N)N)=O)CC(C)C)(=O)[C@H]2N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@@H](NC(=O)[C@H]4N(C([C@H](CCSC)N)=O)CCC4)CC5=CN=CN5)=O)CO)=O)=O)C)=O)CC(N)=O)=O)CC(C)C)=O)CCC2
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GPCR/G Protein > Neuropeptide FF Receptor