Rho-Kinase-IN-2 is a selective inhibitor of Rho Kinase (ROCK) with an IC50 value of 3 nM for ROCK2. This orally active and CNS-permeable compound is significant for investigating the role of ROCK in neurodegenerative disorders, particularly Huntington's disease. Its potent inhibition of this pathway makes it a valuable tool for exploring therapeutic strategies targeting ROCK activity in relevant biological models.
Rho-Kinase-IN-2 is a selective inhibitor of Rho Kinase (ROCK) with an IC50 value of 3 nM for ROCK2. This orally active and CNS-permeable compound is significant for investigating the role of ROCK in neurodegenerative disorders, particularly Huntington's disease. Its potent inhibition of this pathway makes it a valuable tool for exploring therapeutic strategies targeting ROCK activity in relevant biological models.
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