Ricinelaidic acid is a potent leukotriene B4 (LTB4) receptor antagonist, exhibiting a Ki of 2 μM in porcine neutrophil membranes. This compound effectively inhibits LTB4-induced chemotaxis and calcium flux in isolated human neutrophils, with IC50 values of 10 μM and 7 μM, respectively. Additionally, ricinelaidic acid demonstrates the ability to mitigate bronchoconstriction induced by LTB4 in rat models, making it a valuable reagent for studying inflammatory processes and potential therapeutic interventions in respiratory conditions.
Ricinelaidic acid is a potent leukotriene B4 (LTB4) receptor antagonist, exhibiting a Ki of 2 μM in porcine neutrophil membranes. This compound effectively inhibits LTB4-induced chemotaxis and calcium flux in isolated human neutrophils, with IC50 values of 10 μM and 7 μM, respectively. Additionally, ricinelaidic acid demonstrates the ability to mitigate bronchoconstriction induced by LTB4 in rat models, making it a valuable reagent for studying inflammatory processes and potential therapeutic interventions in respiratory conditions.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
