Rigosertib sodium

Catalog No.: A21824

multi-kinase inhibitor

Rigosertib sodium

Rigosertib sodium Chemical Structure

CAS NO. 592542-60-4

Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle.

Availability: In stock

Package Price Qty
5 mg
$63.00
10 mg
$109.00
50 mg
$322.00
100 mg
$644.00
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Biological Activity

Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.12 mL 105.6 mL 211.21 mL
0.5 mM 4.22 mL 21.12 mL 42.24 mL
1 mM 2.11 mL 10.56 mL 21.12 mL
5 mM 0.42 mL 2.11 mL 4.22 mL

*The above data is based on the productmolecular weight 473.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21824
Actions Inhibitor
CAS No. 592542-60-4
Formula C21H24NNaO8S
M. Wt 473.47
Solubility DMSO
Purity >98%
Synonyms ON-01910 sodium, ON01910, ON 01910
SMILES COC1=CC=C(C=C1NCC([O-])=O)CS(/C=C/C2=C(C=C(C=C2OC)OC)OC)(=O)=O.[(E)].[Na+]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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