Rilmenidine-d4 is a deuterium-labeled derivative of Rilmenidine, a selective I1 imidazoline receptor agonist and antihypertensive agent. It exhibits key biological activities including the induction of autophagy and modulation of apoptosis through the pro-apoptotic protein Bax in human leukemic K562 cells. Rilmenidine also operates centrally to reduce sympathetic overactivity and affects renal function by inhibiting the Na+/H+ antiport. This stable isotope is valuable for pharmacokinetic studies and mechanistic investigations in cardiovascular and cancer research.
Rilmenidine-d4 is a deuterium-labeled derivative of Rilmenidine, a selective I1 imidazoline receptor agonist and antihypertensive agent. It exhibits key biological activities including the induction of autophagy and modulation of apoptosis through the pro-apoptotic protein Bax in human leukemic K562 cells. Rilmenidine also operates centrally to reduce sympathetic overactivity and affects renal function by inhibiting the Na+/H+ antiport. This stable isotope is valuable for pharmacokinetic studies and mechanistic investigations in cardiovascular and cancer research.
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