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Publications citing Adooq Products
Rivaroxaban (Xarelto) Citations (2)
- Dani?l Verhoef,et al. Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors, Nat Commun, 2017, 8: 528 28904343
- Mizuki Yamamoto,et al. Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay, Antimicrob Agents Chemother, 2016, Nov; 60(11): 6532-6539 27550352
Chemical Information
| Catalog Num | A10800 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 435.9 |
| Formula | C19H18ClN3O5S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 366789-02-8 |
| Synonyms | BAY 59-7939, Xarelto |
| SMILES code | C1COCC(=O)N1C2=CC=C(C=C2)N3C[[email protected]@H](OC3=O)CNC(=O)C4=CC=C(S4)Cl |
| Chemical Name | (S)-5-chloro-N-{[2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl} thiophene-2-carboxamide |
Description |
Rivaroxaban is an oxazolidinone derivative optimized for inhibiting both free Factor Xa and Factor Xa bound in the prothrombinase complex. | ||||||||||
Targets |
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| Solubility (25°C) * | In vitro | DMSO | 87 mg/mL (199.59 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 0.5% methylcellulose/0.2% Tween 80 | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.94 mL | 114.71 mL | 229.41mL |
| 0.5 mM | 4.59 mL | 22.94 mL | 45.88 mL |
| 1 mM | 2.29 mL | 11.47 mL | 22.94 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.59 mL |
*The above data is based on the productmolecular weight 435.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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