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Rivaroxaban is an oxazolidinone derivative optimized for inhibiting both free Factor Xa and Factor Xa bound in the prothrombinase complex.
Targets
| Factor Xa (Cell-free assay) | Prothrombinase (Cell-free assay) | |||
| 0.7 nM | 2.1 nM |
| In vitro (25°C) | DMSO | 87 mg/mL (199.59 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 0.5% methylcellulose/0.2% Tween 80 | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.94 mL | 114.71 mL | 229.41 mL |
| 0.5 mM | 4.59 mL | 22.94 mL | 45.88 mL |
| 1 mM | 2.29 mL | 11.47 mL | 22.94 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.59 mL |
*The above data is based on the productmolecular weight 435.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A10800 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 435.9 |
| Formula | C19H18ClN3O5S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 366789-02-8 |
| Synonyms | BAY 59-7939, Xarelto |
| SMILES | C1COCC(=O)N1C2=CC=C(C=C2)N3C[[email protected]@H](OC3=O)CNC(=O)C4=CC=C(S4)Cl |
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