Catalog No.
Product Name
Application
Product Information
Product Citation
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Factor Xa inhibitor
Apixaban is an anticoagulant for the prevention of venous thromboembolism and venous thromboembolic events.- Daniël Verhoef, .et al. , Nat Commun, 2017, 8: 528 PMID: 28904343
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Factor Xa inhibitor
BMS-740808 is a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.
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Factor Xa inhibitor
Rivaroxaban is an oxazolidinone derivative optimized for inhibiting both free Factor Xa and Factor Xa bound in the prothrombinase complex.- Stefan Bittmann, .et al. , J Regen Biol Med, 2020, 2(2):1-3
- Daniël Verhoef, .et al. , Nat Commun, 2017, 8: 528 PMID: 28904343
- Mizuki Yamamoto, .et al. , Antimicrob Agents Chemother, 2016, Nov; 60(11): 6532-6539 PMID: 27550352
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factor Xa inhibitor
Otamixaban(FXV 673) is an intravenous direct factor Xa inhibitor.- Tim Hempel, .et al. , Chemical Science, 2021, 12, 12600-12609
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dual inhibitor of thrombin and factor Xa
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity. - Rivaroxaban is an oxazolidinone derivative optimized for inhibiting both free Factor Xa and Factor Xa bound in the prothrombinase complex.
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FXa Inhibitor
Betrixaban is an anticoagulant drug which acts as a direct factor Xa inhibitor. It is potent, orally active and highly selective for factor Xa, being selected from a group of similar compounds for its low hERG affinity. -
factor Xa inhibitor
Letaxaban, also known as TAK-442, is a potent, selective, and orally active factor Xa inhibitor, which is a tetrahydropyrimidin-2(1H)-one derivative. TAK-442 inhibited endogenous FXa activity in platelet-poor human [half-maximal inhibitory concentration (IC(50)): 53 nM, TAK-442] and rat (IC(50): 32 nM, TAK-442) plasma. -
Factor Xa inhibitor
Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM- Daniël Verhoef, .et al. , Nat Commun, 2017, 8: 528 PMID: 28904343
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Factor Xa inhibitor
5-R-Rivaroxaban is (R) enantiomer of Rivaroxaban. Rivaroxaban is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders. -
Factor Xa inhibitor
Edoxaban is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention. -
factor Xa inhibitor
Fondaparinux sodium is a factor Xa inhibitor to form the high affinity binding site for the anti-coagulant factor antithrombin III (ATIII). -
FXIa inhibitor
BMS-962212 is a reversible, direct, and highly selective inhibitor of FXIa. -
Factor XIa (FXIa) inhibitor
BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa), binding with human and rabbit FXIa with Kis of 0.2 and 0.42 nM, respectively.
