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- Yang SNY, .et al. RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X, Cells, 2020, Jan 9;9(1). PMID: 31936642
- Zhang S, .et al. Nuclear bodies formed by polyQ-ataxin-1 protein are liquid RNA/protein droplets with tunable dynamics, Sci Rep, 2020, Jan 31;10(1):1557 PMID: 32005838
Biological Activity
RK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity.
Targets
| DDX3 | ||||
| In vitro | DMSO | 76 mg/mL (177.38 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.34 mL | 116.7 mL | 233.4 mL |
| 0.5 mM | 4.67 mL | 23.34 mL | 46.68 mL |
| 1 mM | 2.33 mL | 11.67 mL | 23.34 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
*The above data is based on the productmolecular weight 428.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16194 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1070773-09-9 |
| Formula | C23H20N6O3 |
| M. Wt | 428.45 |
| Purity | >98% |
| Synonyms | RK 33, RK33 |
| SMILES | O=C1N(CC2=CC=C(OC)C=C2)C3=NC=NC4=C(N=CN4CC5=CC=C(OC)C=C5)C3=N1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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