RL648_81 is a selective activator of the KQT-like subfamily 2/3 (KCNQ2/3) channels, exhibiting an EC50 of 190 nM. This compound effectively induces a hyperpolarizing shift in V1/2 for KCNQ2/3, while showing no effect on KCNQ4 or KCNQ5 channels. RL648_81 holds promise for research involving neurological disorders linked to neuronal hyperexcitability.
RL648_81 is a selective activator of the KQT-like subfamily 2/3 (KCNQ2/3) channels, exhibiting an EC50 of 190 nM. This compound effectively induces a hyperpolarizing shift in V1/2 for KCNQ2/3, while showing no effect on KCNQ4 or KCNQ5 channels. RL648_81 holds promise for research involving neurological disorders linked to neuronal hyperexcitability.
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