Ro 46-8443 is a selective antagonist of the endothelin ETB receptor, exhibiting at least 100-fold selectivity for ETB over ETA receptors (IC50: 34-69 nM vs. 6800 nM). Its specificity allows for targeted investigations into ETB receptor-related biological mechanisms. This compound is valuable for research applications focused on cardiovascular effects, cell proliferation, and pathophysiological conditions related to endothelin signaling.
Ro 46-8443 is a selective antagonist of the endothelin ETB receptor, exhibiting at least 100-fold selectivity for ETB over ETA receptors (IC50: 34-69 nM vs. 6800 nM). Its specificity allows for targeted investigations into ETB receptor-related biological mechanisms. This compound is valuable for research applications focused on cardiovascular effects, cell proliferation, and pathophysiological conditions related to endothelin signaling.
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