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Catalog No.: A11247

MEK1/2 inhibitor


RO4927350 Chemical Structure

CAS NO. 876755-27-0

RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor.

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Biological Activity

RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.64 mL 93.18 mL 186.36 mL
0.5 mM 3.73 mL 18.64 mL 37.27 mL
1 mM 1.86 mL 9.32 mL 18.64 mL
5 mM 0.37 mL 1.86 mL 3.73 mL

*The above data is based on the productmolecular weight 536.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11247
Actions Inhibitor
CAS No. 876755-27-0
Formula C27H28N4O6S
M. Wt 536.6
Purity >98%
Synonyms RO 4927350, RO-4927350
SMILES CCC(=O)C1=CSC(=N1)NC(=O)[[email protected]]([[email protected]@H](C)C2=CC=CC=C2)N3C(=O)[[email protected]](NC3=O)C4=CC=C(C=C4)OCCO

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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