RO5126766 (CH5126766)

Catalog No.: A14019

Raf/MEK dual inhibitor

RO5126766 (CH5126766)

RO5126766 (CH5126766) Chemical Structure

CAS NO. 946128-88-7

RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity.

Availability: In stock

Package Price Qty
5 mg
$140.00
10 mg
$220.00
25 mg
$450.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity.
Targets
BRAF V600E BRAF CRAF MEK1
8.2 nM19 nM56 nM160 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.21 mL 106.04 mL 212.09 mL
0.5 mM 4.24 mL 21.21 mL 42.42 mL
1 mM 2.12 mL 10.6 mL 21.21 mL
5 mM 0.42 mL 2.12 mL 4.24 mL

*The above data is based on the productmolecular weight 471.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A14019
Actions Inhibitor
M. Wt 471.5
Formula C21H18FN5O5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 946128-88-7
Synonyms RO 5126766, RO-5126766, CH5126766, CH-5126766, CH 5126766.
SMILES CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F

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