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RO5126766 (CH5126766)

Catalog No.: A14019

Raf/MEK dual inhibitor

RO5126766 (CH5126766)

RO5126766 (CH5126766) Chemical Structure

CAS NO. 946128-88-7

RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity.

Availability: In stock

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5 mg

Regular Price: $140.00

Special Price $112.00

10 mg

Regular Price: $220.00

Special Price $176.00

25 mg

Regular Price: $450.00

Special Price $360.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767

Biological Activity

RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity.
Targets
BRAF V600E BRAF CRAF MEK1
8.2 nM19 nM56 nM160 nM
In vitro (25°C) DMSO 93 mg/mL (197.26 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+45% PEG 300+ddH2O 19 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.21 mL 106.04 mL 212.09 mL
0.5 mM 4.24 mL 21.21 mL 42.42 mL
1 mM 2.12 mL 10.6 mL 21.21 mL
5 mM 0.42 mL 2.12 mL 4.24 mL

*The above data is based on the productmolecular weight 471.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14019
Actions Inhibitor
CAS No. 946128-88-7
Formula C21H18FN5O5S
M. Wt 471.5
Purity >98%
Synonyms RO 5126766, RO-5126766, CH5126766, CH-5126766, CH 5126766.
SMILES CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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