ROC-0929 is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s), specifically targeting hGX with an IC50 of 80 nM. By inhibiting the phosphorylation of ERK1/2 and p-38, ROC-0929 demonstrates significant anti-inflammatory activity. This compound holds promise for investigating the role of sPLA2s in inflammation-related diseases, making it a valuable tool for research in this area.
ROC-0929 is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s), specifically targeting hGX with an IC50 of 80 nM. By inhibiting the phosphorylation of ERK1/2 and p-38, ROC-0929 demonstrates significant anti-inflammatory activity. This compound holds promise for investigating the role of sPLA2s in inflammation-related diseases, making it a valuable tool for research in this area.
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