Roflumilast-d4 is a deuterium-labeled derivative of Roflumilast, a selective phosphodiesterase 4 (PDE4) inhibitor. This compound exhibits potent inhibitory activity with IC50 values of 0.7 nM for PDE4A1, 0.9 nM for PDE4A, 0.7 nM for PDEB1, and 0.2 nM for PDEB2, demonstrating its specificity as it does not impact PDE1, PDE2, PDE3, or PDE5 isoenzymes across various cell types. Roflumilast-d4 is primarily used as a stable isotope internal standard in pharmacokinetic studies and drug metabolism research.
Roflumilast-d4 is a deuterium-labeled derivative of Roflumilast, a selective phosphodiesterase 4 (PDE4) inhibitor. This compound exhibits potent inhibitory activity with IC50 values of 0.7 nM for PDE4A1, 0.9 nM for PDE4A, 0.7 nM for PDEB1, and 0.2 nM for PDEB2, demonstrating its specificity as it does not impact PDE1, PDE2, PDE3, or PDE5 isoenzymes across various cell types. Roflumilast-d4 is primarily used as a stable isotope internal standard in pharmacokinetic studies and drug metabolism research.
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