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NK1 receptor antagonist

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Catalog No. A13680

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Rolapitant 5mg A13680-5

Regular Price: $120.00

Special Price: $108.00

Rolapitant 10mg A13680-10

Regular Price: $190.00

Special Price: $171.00

Rolapitant 25mg A13680-25

Regular Price: $350.00

Special Price: $315.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Rolapitant, also known as SCH-619734, is a selective, bioavailable, CNS penetrant neurokinin NK1 receptor antagonist that shows behavioral effects in animals models of emesis.


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Publications citing Adooq Products
Rolapitant Citations (1)
  • Bubak AN, .et al. Varicella Zoster Virus Induces Nuclear Translocation of the Neurokinin-1 Receptor, Promoting Lamellipodia Formation and Viral Spread in Spinal Astrocytes, J Infect Dis, 2018, Sep 8;218(8):1324-1335 PMID: 29788447

Chemical Information

Catalog Num A13680
Actions Antagonist
M. Wt 536.94
Formula C25H27ClF6N2O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 552292-08-7
Synonyms SCH619734, SCH-619734, SCH 619734
SMILES C[[email protected]](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC[[email protected]]2(CC[[email protected]]3(CCC(=O)N3)CN2)C4=CC=CC=C4

Biological Activity

Rolapitant, also known as SCH-619734, is a selective, bioavailable, CNS penetrant neurokinin NK1 receptor antagonist that shows behavioral effects in animals models of emesis.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.62 mL 93.12 mL 186.24mL
0.5 mM 3.72 mL 18.62 mL 37.25 mL
1 mM 1.86 mL 9.31 mL 18.62 mL
5 mM 0.37 mL 1.86 mL 3.72 mL

*The above data is based on the productmolecular weight 536.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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