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- Bubak AN, .et al. Varicella Zoster Virus Induces Nuclear Translocation of the Neurokinin-1 Receptor, Promoting Lamellipodia Formation and Viral Spread in Spinal Astrocytes, J Infect Dis, 2018, Sep 8;218(8):1324-1335 PMID: 29788447
Biological Activity
Rolapitant, also known as SCH-619734, is a selective, bioavailable, CNS penetrant neurokinin NK1 receptor antagonist that shows behavioral effects in animals models of emesis.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.98 mL | 99.9 mL | 199.8 mL |
| 0.5 mM | 4 mL | 19.98 mL | 39.96 mL |
| 1 mM | 2 mL | 9.99 mL | 19.98 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
*The above data is based on the productmolecular weight 500.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13680 |
|---|---|
| Actions | Antagonist |
| CAS No. | 552292-08-7 |
| Formula | C25H26F6N2O2 |
| M. Wt | 500.5 |
| Purity | >98% |
| Synonyms | SCH619734, SCH-619734, SCH 619734 |
| SMILES | C[[email protected]](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC[[email protected]]2(CC[[email protected]]3(CCC(=O)N3)CN2)C4=CC=CC=C4 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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