Rosiglitazone-d3 is a deuterium-labeled derivative of Rosiglitazone, a selective and orally active agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It exhibits EC50 values of 30 nM, 100 nM, and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, with a binding affinity (Kd) of approximately 40 nM. In addition to its PPARγ activity, Rosiglitazone also activates TRPC5 with an EC50 of around 30 μM and inhibits TRPM3, making it a valuable tool for investigating metabolic and cardiovascular diseases.
Rosiglitazone-d3 is a deuterium-labeled derivative of Rosiglitazone, a selective and orally active agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It exhibits EC50 values of 30 nM, 100 nM, and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, with a binding affinity (Kd) of approximately 40 nM. In addition to its PPARγ activity, Rosiglitazone also activates TRPC5 with an EC50 of around 30 μM and inhibits TRPM3, making it a valuable tool for investigating metabolic and cardiovascular diseases.
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