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Biological Activity
Rosuvastatin (Crestor) is a member of the drug class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease. Rosuvastatin is a competitive inhibitor of the enzyme HMG-CoA reductase, having a mechanism of action similar to that of other statins.
| In vitro (25°C) | DMSO | Warmed: 91 mg/mL (181.79 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 4% DMSO+30% PEG 300+dd H2O | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.94 mL | 99.7 mL | 199.4 mL |
| 0.5 mM | 3.99 mL | 19.94 mL | 39.88 mL |
| 1 mM | 1.99 mL | 9.97 mL | 19.94 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.99 mL |
*The above data is based on the productmolecular weight 501.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10810 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 147098-20-2 |
| Formula | C22H28FN3O6S.1/2Ca |
| M. Wt | 501.5 |
| Purity | >98% |
| SMILES | CC(C1=NC(=NC(=C1/C=C/[[email protected]@H](O)C[[email protected]@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.CC(C1=NC(=NC(=C1/C=C/[[email protected]@H](O)C[[email protected]@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.[Ca+2] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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