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RPR-200765A methanesulfonate

Catalog No.: A40842
p38 MAPK Inhibitor
RPR-200765A methanesulfonate is a potent inhibitor of p38 MAPK, demonstrating an IC50 of 0.050 μM. This compound selectively targets the p38 MAPK pathway while showing minimal activity against Lck, ERK, ZAP70, and SYK. RPR-200765A methanesulfonate effectively inhibits TNFα production, making it a valuable tool for investigating inflammatory diseases and related cellular processes.
RPR-200765A methanesulfonate 218162-38-0 p38 MAPK Inhibitor
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRPR-200765A methanesulfonate is a potent inhibitor of p38 MAPK, demonstrating an IC50 of 0.050 μM. This compound selectively targets the p38 MAPK pathway while showing minimal activity against Lck, ERK, ZAP70, and SYK. RPR-200765A methanesulfonate effectively inhibits TNFα production, making it a valuable tool for investigating inflammatory diseases and related cellular processes.
Product Information
Catalog NumA40842
FormulaC25H29FN4O7S
Molecular Weight548.58
CAS Number218162-38-0
SMILESO=C([C@@]1(C)CO[C@@H](C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)OC1)N5CCOCC5.CS(=O)(O)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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    V2

MAPK > p38-MAPK