RS 49676 is an N-substituted imidazole compound that acts as a potent inhibitor against endogenous amoebae, displaying an ED50 of less than 0.1 ng/mL. It demonstrates significant biological activity in vivo, notably prolonging the average survival time of mice infected with Trypanosoma cruzi to over 11 weeks when administered at a dose of 100 mg/kg per day via subcutaneous injection. This compound is valuable for research applications involving parasitic infections and host-pathogen interactions.
RS 49676 is an N-substituted imidazole compound that acts as a potent inhibitor against endogenous amoebae, displaying an ED50 of less than 0.1 ng/mL. It demonstrates significant biological activity in vivo, notably prolonging the average survival time of mice infected with Trypanosoma cruzi to over 11 weeks when administered at a dose of 100 mg/kg per day via subcutaneous injection. This compound is valuable for research applications involving parasitic infections and host-pathogen interactions.
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