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  1. Derivative of artemisinin

    Artemether has been shown to have significant anticancer and antitumor activities. It is demonstrated that artemether caused strong inhibitory effects on brain glioma growth and angiogenesis in rats.
  2. nitroimidazole antibiotic medication

    Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa.
  3. Pyrantel pamoate is a deworming agent in the treatment of hookworms (all species) and roundworms in domesticated animal; acts as a depolarizing neuromuscular blocking agent.
  4. Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.
  5. Doramectin is an antiparasitic agent.
  6. Toltrazuril sulfone is an antiprotozoal agent that acts upon Coccidia parasites.
  7. AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum.
  8. Ferroquine is an ingenious antimalarial agent.
  9. 2'-Hydroxy-4'-methylacetophenone, a phenolic compound isolated from Angelicae koreana roots possesses acaricidal property. It could be used in the preparation of 4??-methyl-2??-[(p-tolylsulfonyl) oxy] acetophenone.
  10. PKG inhibitor

    MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases.
  11. Sulfaclozine (Sulfachloropyrazine) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis).
  12. SK channel inhibitor

    ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 ?M.
  13. Anti-Wolbachia agent

    AWZ1066S is a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis, with an EC50 of 2.5 nM in cell assay.
  14. Prodigiosin (Prodigiosine) is a secondary metabolite of Symbiotic bacteria, with anti-fungal and anti-cancer activity.
  15. Arterolane is an antimalarial agent, with IC50 of both 1.1 nM against P. falciparum Ro73 and W2, respectively.
  16. arachidonic acid metabolism inhibitor

    Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria; is highly specific for several parasites and does not contain any toxic metallic elements.
  17. Primaquine is the only generally available anti-malarial that prevents relapse in vivax and ovale malaria, and the only potent gametocytocide in falciparum malaria.
  18. plasmodium ATP4 inhibitor

    (+)-SJ733 is an inhibitor of plasmodium ATP4, leading to rapid clearance in vivo by inducing physical changes in infected, treated red cells.
  19. Sulfalene is an antimalarial agent.
  20. anthelmintic

    Oxyclozanide is a salicylanilide anthelmintic that is a proton ionophore which uncouples oxidative phosphorylation of the target organism.
  21. protein kinase A inhibitor

    Warangalone is a prenylated isoflavone from the insecticidal plant Derris scandens that acts as a powerful inhibitor of protein kinase A.
  22. Antibiotic

    Sulfaquinoxaline sodium salt is an antibiotic which has activity against a broad spectrum of Gram-negative and Gram-positive bacteria.
  23. Antibiotic

    Robenidine hydrochloride is an antibiotic used for the control of coccidiosis, a debilitating protozoal infection in poultry.
  24. Antimalarial

    Quinine is a primary alkaloid of various species of Cinchona, optical isomer of Quinidine and an anti-malarial, skeletal, muscle relaxant.
  25. folate metabolism inhibitor

    Ethopabate is a folate metabolism inhibitor used in the prophylaxis and treatment of coccidiosis in chickens.
  26. Benznidazol (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease.
  27. Lumefantrine, also known as HSDB 7210, is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.
  28. Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant Plasmodium falciparum malaria with an IC50 of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys.
  29. insecticide

    Azamethiphos is an organothiophosphate insecticide. It is a veterinary drug used in Atlantic salmon fish farming to control parasites.
  30. oral anthelmintic

    Febantel is an oral anthelmintic. It is a prodrug metabolised in vivo to fenbendazole. Febantel is used for the treatment and control of gastro-intestinal roundworms, lung worms and tapeworms.
  31. Antiparasitic

    Rafoxanide is a salicylanilide used as an anthelmintic. It is used to treat fluke, hookworm and other infestations.
  32. Tyrosinase inhibitor

    Kojic Acid is a tyrosinase inhibitor. It is a chelation agent produced by several species of fungi, especially Aspergillus oryzae, which has the Japanese common name koji.
  33. Oxantel Pamoate is an anthelmintic used to treat Trichuris trichiura infection.
  34. L-(-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions.
  35. Permethrin is a widely-used pesticide of the pyrethroid family.
  36. Santonin is an Anthelmintic isolated from the dried unexpanded flower heads of Artemisia maritima and other species of Artemisia found principally in Russian and Chinese Turkestan and the Southern Ural region.
  37. N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively.
  38. BPH-715 is a new generation of lipophilic bisphosphonates designed as anticancer agents that block protein prenylation also have potent activity against Plasmodium liver stages.
  39. Lotilaner is an insecticide (veterinary drug).
  40. AN7973 is the 6-carboxamide benzoxaborole, blocks intracellular parasite development and inhibits Cryptosporidium growth. AN7973 is orally active, possesses favorable safety, stability, and PK parameters, and is an exciting drug candidate for treating cryptosporidiosis.
  41. Chalcone 4 hydrate is an anti-parasite agent, inhibits the growth of Babesia and Theileria.
  42. Quinfamide is an antiamebic agent. Quinfamide can be used to treat tropical parasitic infections such as Amoebiasis and Helminthiasis.
  43. Symetine is an antiparasitic and antispirochete agent.
  44. virion mRNA(guanine-7-)-methyltransferase inhibitor

    Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication.
  45. Panidazole is an amoebicide.
  46. CRK12 inhibitor

    GSK3186899 (DDD-853651) is an inhibitor of cdc-2-related kinase 12 (CRK12), with an EC50 of 1.4 μM for L. donovani in an intra-macrophage assay.
  47. PKA activator

    Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity.
  48. ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
  49. Emodepside (PF 1022-221) is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity.
  50. Asparagusic acid (1,2-dithiolane-4-carboxylic acid) is unique to asparagus. The compound is responsible for the odorous urine excreted after eating asparagus. Its derivatives ihydroasparagusic acid have anti-inflammatory effect.

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