Ruxolitinib-d9 is a deuterium-labeled derivative of Ruxolitinib, a selective JAK1/2 inhibitor. With IC50 values of 3.3 nM and 2.8 nM for JAK1 and JAK2 respectively, Ruxolitinib demonstrates a significant preference for these targets over JAK3, exhibiting a 130-fold selectivity. This compound plays a critical role in cancer research by inducing autophagy and promoting cell death in tumor cells through mechanisms of toxic mitophagy.
Ruxolitinib-d9 is a deuterium-labeled derivative of Ruxolitinib, a selective JAK1/2 inhibitor. With IC50 values of 3.3 nM and 2.8 nM for JAK1 and JAK2 respectively, Ruxolitinib demonstrates a significant preference for these targets over JAK3, exhibiting a 130-fold selectivity. This compound plays a critical role in cancer research by inducing autophagy and promoting cell death in tumor cells through mechanisms of toxic mitophagy.
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