RWJ-671818

Catalog No.: A77961
α-thrombin Inhibitor
RWJ-671818 is a potent oral inhibitor of human α-thrombin, exhibiting a Ki of 1.3 nM. This compound is particularly relevant in the study of venous and arterial thrombosis, providing insights into thrombotic mechanisms and potential therapeutic interventions. Its specificity for α-thrombin makes it a valuable tool in anticoagulant research.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRWJ-671818 is a potent oral inhibitor of human α-thrombin, exhibiting a Ki of 1.3 nM. This compound is particularly relevant in the study of venous and arterial thrombosis, providing insights into thrombotic mechanisms and potential therapeutic interventions. Its specificity for α-thrombin makes it a valuable tool in anticoagulant research.
Product Information
Catalog NumA77961
FormulaC18H23F2N7O3
Molecular Weight423.42
CAS Number252271-49-1
SMILESO=C(CN1C(C(NCC(F)(C2=CC=CC=C2)F)=NC=C1C)=O)NCCONC(N)=N
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