S 16317 is an orally active dihydropyridine derivative that demonstrates low affinity for calcium channels (Ki: 0.55 μM). It effectively inhibits P-glycoprotein-mediated efflux of doxorubicin (ADR), thus potentially reversing multidrug resistance in tumor cells. This compound is particularly relevant for research in cancer biology and the development of novel therapeutic strategies against resistant tumors.
S 16317 is an orally active dihydropyridine derivative that demonstrates low affinity for calcium channels (Ki: 0.55 μM). It effectively inhibits P-glycoprotein-mediated efflux of doxorubicin (ADR), thus potentially reversing multidrug resistance in tumor cells. This compound is particularly relevant for research in cancer biology and the development of novel therapeutic strategies against resistant tumors.
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