(S,E)-Cyclooct-2-enol is a click chemistry reagent that serves as a versatile linker in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. The compound features a TCO (trans-cyclooctene) moiety, which is capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-modified partners. This property is essential for the development of targeted protein degradation strategies in chemical biology research.
(S,E)-Cyclooct-2-enol is a click chemistry reagent that serves as a versatile linker in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. The compound features a TCO (trans-cyclooctene) moiety, which is capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-modified partners. This property is essential for the development of targeted protein degradation strategies in chemical biology research.
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