(S,R,S)-AHPC-O-Ph-PEG1-NH2 is an E3 ligase ligand-linker conjugate, designed to incorporate a VHL ligand that targets the E3 ubiquitin ligase. This compound serves as a critical component in the development of PROTAC molecules, specifically utilized in the PROTAC EED degrader-1, which targets the EED protein with a pKD of 9.02. Its application is relevant in studies of targeted protein degradation and cellular signaling pathways, making it valuable for research in cancer and other diseases influenced by protein homeostasis.
(S,R,S)-AHPC-O-Ph-PEG1-NH2 is an E3 ligase ligand-linker conjugate, designed to incorporate a VHL ligand that targets the E3 ubiquitin ligase. This compound serves as a critical component in the development of PROTAC molecules, specifically utilized in the PROTAC EED degrader-1, which targets the EED protein with a pKD of 9.02. Its application is relevant in studies of targeted protein degradation and cellular signaling pathways, making it valuable for research in cancer and other diseases influenced by protein homeostasis.
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