σ1 Receptor/μ Opioid receptor modulator 2 is a dual μ-opioid receptor (μOR) agonist and σ1 receptor (σ1R) antagonist. It demonstrates potent μOR agonistic activity with an EC50 value of 0.6 ± 0.2 nM and effective σ1R inhibitory activity at a Ki of 363.7 ± 5.6 nM. This compound exhibits significant analgesic effects in multiple preclinical pain models, making it a valuable tool for research in pain management and opioid receptor pharmacology.
σ1 Receptor/μ Opioid receptor modulator 2 is a dual μ-opioid receptor (μOR) agonist and σ1 receptor (σ1R) antagonist. It demonstrates potent μOR agonistic activity with an EC50 value of 0.6 ± 0.2 nM and effective σ1R inhibitory activity at a Ki of 363.7 ± 5.6 nM. This compound exhibits significant analgesic effects in multiple preclinical pain models, making it a valuable tool for research in pain management and opioid receptor pharmacology.
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