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SAH-EZH2

Catalog No.: A26706
EZH2/EED Interaction Inhibitor
SAH-EZH2 is an EZH2/EED interaction inhibitor designed to disrupt the binding between embryonic ectoderm development (EED) and the EZH1/EZH2 complex. This stable α-helical peptide selectively inhibits the trimethylation of histone H3 at lysine 27 (H3K27me3), providing a valuable tool for studying epigenetic regulation. SAH-EZH2 is applicable in research focused on developmental biology and the mechanisms of cancer progression related to the regulation of gene expression by histone modifications.
SAH-EZH2 1453222-26-8 EZH2/EED Interaction Inhibitor
Grouped product items
Size Price Stock Qty
1mg
$195.00
In stock
5mg
$505.00
In stock
10mg
$825.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSAH-EZH2 is an EZH2/EED interaction inhibitor designed to disrupt the binding between embryonic ectoderm development (EED) and the EZH1/EZH2 complex. This stable α-helical peptide selectively inhibits the trimethylation of histone H3 at lysine 27 (H3K27me3), providing a valuable tool for studying epigenetic regulation. SAH-EZH2 is applicable in research focused on developmental biology and the mechanisms of cancer progression related to the regulation of gene expression by histone modifications.
Product Information
Catalog NumA26706
FormulaC155H256N48O40
Molecular Weight3431.99
CAS Number1453222-26-8
Sequence shorteningAc-FSSNR-{(S)-2-(4ʹ-pentenyl)Ala}-KIL-{(S)-2-(4ʹ-pentenyl)Ala}-RTQILNQEWKQRRIQPV (Covalent bridge: Ala6-Ala10)
SMILESC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@@]1(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@H](CCCCN)NC(=O)[C@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC(C)=O)=O)CO)=O)CO)=O)CC(N)=O)=O)CCCNC(=N)N)=O)(C)CCCC=CCCC1)[H])CCCNC(=N)N)=O)[C@@H](C)O)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)CC(N)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@@H](C(C)C)C(O)=O)=O)CCC3)CCC(N)=O)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCCN)=O)C=4C=5C(NC4)=CC=CC5
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Epigenetics > Histone Methyltransferase