SAL-0010042 is a potent inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP with an IC50 of 48.9 nM in gametocytes. This compound activates protein kinase G (PKG) and demonstrates significant inhibitory effects on the growth and development of Plasmodium, with IC50 values of 142 nM and 218 nM for the 3D7 and Dd2 strains, respectively. Additionally, SAL-0010042 also inhibits human phosphodiesterases hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, making it valuable for research in malaria and related diseases.
SAL-0010042 is a potent inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP with an IC50 of 48.9 nM in gametocytes. This compound activates protein kinase G (PKG) and demonstrates significant inhibitory effects on the growth and development of Plasmodium, with IC50 values of 142 nM and 218 nM for the 3D7 and Dd2 strains, respectively. Additionally, SAL-0010042 also inhibits human phosphodiesterases hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, making it valuable for research in malaria and related diseases.
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