Salubrinal

Catalog No.: A12676

eIF2α dephosphorylation inhibitor

Salubrinal

Salubrinal Chemical Structure

CAS NO. 405060-95-9

Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).

Availability: In stock

Package Price Qty
10 mg

Regular Price: $100.00

Special Price $80.00

25 mg

Regular Price: $200.00

Special Price $160.00

50 mg

Regular Price: $350.00

Special Price $280.00

100 mg

Regular Price: $600.00

Special Price $480.00

10mM * 1mL in DMSO
$69.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).
Targets
eIF2α (Cell-free assay)
In vitro DMSO 96 mg/mL (200.07 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (4.16 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 125.3 mL 626.49 mL 1252.98 mL
0.5 mM 25.06 mL 125.3 mL 250.6 mL
1 mM 12.53 mL 62.65 mL 125.3 mL
5 mM 2.51 mL 12.53 mL 25.06 mL

*The above data is based on the productmolecular weight 79.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A12676
Actions Inhibitor
M. Wt 79.81
Formula C21H17N4OSCl3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 405060-95-9
Synonyms N/A
SMILES C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3

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