SANT-1

Catalog No.: A13095

Sonic hedgehog inhibitor

SANT-1

SANT-1 Chemical Structure

CAS NO. 304909-07-7

SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).

Availability: In stock

Package Price Qty
10 mg

Regular Price: $100.00

Special Price $80.00

25 mg

Regular Price: $200.00

Special Price $160.00

50 mg

Regular Price: $350.00

Special Price $280.00

100 mg

Regular Price: $600.00

Special Price $480.00

10mM * 1mL in DMSO
$96.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
Targets
Smoothened receptor
1.2 nM(Kd)
In vitro DMSO 21 mg/mL (56.22 mM)
Water <1 mg/mL (<1 mM)
Ethanol 20 mg/mL (53.54 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.77 mL 133.87 mL 267.74 mL
0.5 mM 5.35 mL 26.77 mL 53.55 mL
1 mM 2.68 mL 13.39 mL 26.77 mL
5 mM 0.54 mL 2.68 mL 5.35 mL

*The above data is based on the productmolecular weight 373.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A13095
Actions Inhibitor
M. Wt 373.5
Formula C23H27N5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 304909-07-7
Synonyms SANT 1, SANT1
SMILES CC1=C(C(=NN1C2=CC=CC=C2)C)/C=N/N3CCN(CC3)CC4=CC=CC=C4

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