SAR245409 (XL765, Voxtalisib)
Catalog No.: A16276
PI3K/mTOR dual inhibitor
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Biological Activity
| Description | SAR245409 is a PI3K/mTOR dual kinase inhibitor XL765 is an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. | ||
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| Targets |
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Product Information
| Catalog Num | A16276 |
|---|---|
| Formula | C13H14N6O |
| Molecular Weight | 270.29 |
| CAS Number | 934493-76-2 |
| SMILES | O=C1C(C2=NNC=C2)=CC3=C(C)N=C(N)N=C3N1CC |
| Synonyms | Voxtalisib, XL765, SAR 245409, SAR-245409, XL 765, XL-765 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro | DMSO | 53 mg/mL (196.08 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37 mL | 184.99 mL | 369.97 mL |
| 0.5 mM | 7.4 mL | 37 mL | 73.99 mL |
| 1 mM | 3.7 mL | 18.5 mL | 37 mL |
| 5 mM | 0.74 mL | 3.7 mL | 7.4 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
