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SAR245409 is a PI3K/mTOR dual kinase inhibitor XL765 is an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity.
Targets
| Target | Value |
|---|---|
| PI3Kγ | IC50: 9nM |
| PI3Kα | IC50: 39nM |
| PI3Kδ | IC50: 43nM |
| PI3Kβ | IC50: 113nM |
| DNA-PK | IC50: 150nM |
| mTOR | IC50: 157nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37 mL | 184.99 mL | 369.97 mL |
| 0.5 mM | 7.4 mL | 37 mL | 73.99 mL |
| 1 mM | 3.7 mL | 18.5 mL | 37 mL |
| 5 mM | 0.74 mL | 3.7 mL | 7.4 mL |
*The above data is based on the productmolecular weight 270.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16276 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 270.29 |
| Formula | C13H14N6O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 934493-76-2 |
| Synonyms | Voxtalisib, XL765, SAR 245409, SAR-245409, XL 765, XL-765 |
| SMILES | O=C1C(C2=NNC=C2)=CC3=C(C)N=C(N)N=C3N1CC |
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