SAR245409 (XL765, Voxtalisib)

Catalog No.: A16276

PI3K/mTOR dual inhibitor

SAR245409 (XL765, Voxtalisib)

SAR245409 (XL765, Voxtalisib) Chemical Structure

CAS NO. 934493-76-2

SAR245409 is a PI3K/mTOR dual kinase inhibitor XL765 is an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$140.00
50 mg
$415.00
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Biological Activity

SAR245409 is a PI3K/mTOR dual kinase inhibitor XL765 is an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity.
Targets
Target Value
PI3KγIC50: 9nM
PI3KαIC50: 39nM
PI3KδIC50: 43nM
PI3KβIC50: 113nM
DNA-PKIC50: 150nM
mTORIC50: 157nM
In vitro DMSO 53 mg/mL (196.08 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37 mL 184.99 mL 369.97 mL
0.5 mM 7.4 mL 37 mL 73.99 mL
1 mM 3.7 mL 18.5 mL 37 mL
5 mM 0.74 mL 3.7 mL 7.4 mL

*The above data is based on the productmolecular weight 270.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16276
Actions Inhibitor
CAS No. 934493-76-2
Formula C13H14N6O
M. Wt 270.29
Purity >98%
Synonyms Voxtalisib, XL765, SAR 245409, SAR-245409, XL 765, XL-765
SMILES O=C1C(C2=NNC=C2)=CC3=C(C)N=C(N)N=C3N1CC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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