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SAR245409 is a PI3K/mTOR dual kinase inhibitor XL765 is an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity.
Targets
| Target | Value |
|---|---|
| PI3Kγ | IC50: 9nM |
| PI3Kα | IC50: 39nM |
| PI3Kδ | IC50: 43nM |
| PI3Kβ | IC50: 113nM |
| DNA-PK | IC50: 150nM |
| mTOR | IC50: 157nM |
| In vitro | DMSO | 53 mg/mL (196.08 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37 mL | 184.99 mL | 369.97 mL |
| 0.5 mM | 7.4 mL | 37 mL | 73.99 mL |
| 1 mM | 3.7 mL | 18.5 mL | 37 mL |
| 5 mM | 0.74 mL | 3.7 mL | 7.4 mL |
*The above data is based on the productmolecular weight 270.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16276 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 934493-76-2 |
| Formula | C13H14N6O |
| M. Wt | 270.29 |
| Purity | >98% |
| Synonyms | Voxtalisib, XL765, SAR 245409, SAR-245409, XL 765, XL-765 |
| SMILES | O=C1C(C2=NNC=C2)=CC3=C(C)N=C(N)N=C3N1CC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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