SAR405

Catalog No.: A21345

PI3KC3 isoform Vps34 inhibitor

SAR405

SAR405 Chemical Structure

CAS NO. 1523406-39-4

SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PI3KC3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM).

Availability: In stock

Package Price Qty
2 mg

Regular Price: $81.00

Special Price $64.80

5 mg

Regular Price: $162.00

Special Price $129.60

10 mg

Regular Price: $315.00

Special Price $252.00

50 mg

Regular Price: $927.00

Special Price $741.60

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Biological Activity

SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PI3KC3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM).
In vitro (25°C) DMSO Warmed: 76 mg/mL (171.22 mM)
Water Insoluble
Ethanol 76 mg/mL (171.22 mM)
In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.53 mL 112.65 mL 225.3 mL
0.5 mM 4.51 mL 22.53 mL 45.06 mL
1 mM 2.25 mL 11.27 mL 22.53 mL
5 mM 0.45 mL 2.25 mL 4.51 mL

*The above data is based on the productmolecular weight 443.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21345
Actions Inhibitor
CAS No. 1523406-39-4
Formula C19H21ClF3N5O2
M. Wt 443.85
Solubility DMSO
Purity >98%
Synonyms SAR 405, SAR-405
SMILES O=C1N(C2=NC(N3[[email protected]](C)COCC3)=C1)CC[[email protected]@H](C(F)(F)F)N2CC4=CC(Cl)=CN=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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