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Publications citing Adooq Products
Chemical Information
| Catalog Num | A10825 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 371.2 |
| Formula | C19H12Cl2N2O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 280744-09-4 |
| Synonyms | SB-216763, SB216763 |
| SMILES | CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl |
Description |
SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β). | ||||||||||
Targets |
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| Solubility (25°C) * | In vitro | DMSO | 23 mg/mL (61.95 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 1% DMSO/30% polyethylene glycol/1% Tween 80 | 11 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.94 mL | 134.7 mL | 269.4mL |
| 0.5 mM | 5.39 mL | 26.94 mL | 53.88 mL |
| 1 mM | 2.69 mL | 13.47 mL | 26.94 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.39 mL |
*The above data is based on the productmolecular weight 371.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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