SB-505124

Catalog No.: A11157

ALK5 inhibitor

SB-505124

SB-505124 Chemical Structure

CAS NO. 694433-59-5

SB-505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $60.00

Special Price $54.00

25 mg

Regular Price: $220.00

Special Price $198.00

50 mg

Regular Price: $400.00

Special Price $360.00

100 mg

Regular Price: $720.00

Special Price $648.00

10mM * 1mL in DMSO

Regular Price: $99.00

Special Price $89.10

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

SB-505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively).
Targets
ALK5 (Cell-free assay) ALK4 (Cell-free assay)
47 nM129 nM
In vitro (25°C) DMSO 67 mg/mL (199.76 mM)
Water <1 mg/mL (<1 mM)
Ethanol 67 mg/mL (199.76 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.82 mL 149.08 mL 298.15 mL
0.5 mM 5.96 mL 29.82 mL 59.63 mL
1 mM 2.98 mL 14.91 mL 29.82 mL
5 mM 0.6 mL 2.98 mL 5.96 mL

*The above data is based on the productmolecular weight 335.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11157
Actions Inhibitor
M. Wt 335.4
Formula C20H21N3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 694433-59-5
Synonyms SB505124
SMILES CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=C(C=C3)OCO4

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