SB 525334

Catalog No.: A10827

ALK Inhibitor

SB 525334

SB 525334 Chemical Structure

CAS NO. 356559-20-1

SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells

Availability: In stock

Package Price Qty
5 mg
$50.00
10 mg
$90.00
50 mg
$300.00
100 mg
$500.00
10mM * 1mL in DMSO
$60.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells
Targets
TGFβR1(ALK5) (Cell-free assay)
14.3 nM
In vitro (25°C) DMSO 67 mg/mL (195.09 mM)
Water Insoluble
Ethanol 67 mg/mL (195.09 mM)
In vivo 5% DMSO+corn oil 19 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.12 mL 145.6 mL 291.21 mL
0.5 mM 5.82 mL 29.12 mL 58.24 mL
1 mM 2.91 mL 14.56 mL 29.12 mL
5 mM 0.58 mL 2.91 mL 5.82 mL

*The above data is based on the productmolecular weight 343.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10827
Actions Inhibitor
CAS No. 356559-20-1
Formula C21H21N5
M. Wt 343.4
Purity >98%
Synonyms SB-525334, SB525334
SMILES CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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