Biological Activity
SB-705498 is a potent, selective and orally bioavailable TRPV1 antagonist.
Targets
hTRPV1 | hTRPV1 | |||
7.6(pKi) | 7.1(pIC50) |
In vitro | DMSO | 78 mg/mL (181.71 mM) | |
Water | Insoluble | ||
Ethanol | 18 mg/mL (41.93 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.36 mL | 116.82 mL | 233.64 mL |
0.5 mM | 4.67 mL | 23.36 mL | 46.73 mL |
1 mM | 2.34 mL | 11.68 mL | 23.36 mL |
5 mM | 0.47 mL | 2.34 mL | 4.67 mL |
*The above data is based on the productmolecular weight 428.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11143 |
---|---|
Actions | Antagonist |
CAS No. | 501951-42-4 |
Formula | C17H16BrF3N4O |
M. Wt | 428.0 |
Purity | >98% |
Synonyms | SB705498 |
SMILES | C1CN(C[[email protected]@H]1NC(=O)NC2=CC=CC=C2Br)C3=NC=C(C=C3)C(F)(F)F |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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