SBI-0206965

Catalog No.: A15795

ULK1 inhibitor

SBI-0206965

SBI-0206965 Chemical Structure

CAS NO. 1884220-36-3

SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 .

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5 mg
$100.00
10 mg
$180.00
25 mg
$360.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • SR Bonam, .et al. Progress and Challenges in the Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo, Cells, 2020, May; 9(5): 1321 PMID: 32466347
  • Altea Rocchi, .et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease, PLoS Genet, 2017, Aug; 13(8): e1006962 PMID: 28806762

Biological Activity

SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 .
In vitro DMSO 90 mg/mL (183.92 mM)
Water Insoluble
Ethanol Warmed: 9 mg/mL (18.39 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.44 mL 102.18 mL 204.37 mL
0.5 mM 4.09 mL 20.44 mL 40.87 mL
1 mM 2.04 mL 10.22 mL 20.44 mL
5 mM 0.41 mL 2.04 mL 4.09 mL

*The above data is based on the productmolecular weight 489.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15795
Actions Inhibitor
CAS No. 1884220-36-3
Formula C21H21BrN4O5
M. Wt 489.32
Solubility DMSO
Purity >98%
Synonyms SBI 0206965, SBI0206965
SMILES CNC(=O)C1=CC=CC=C1OC2=NC(=NC=C2Br)NC3=CC(=C(C(=C3)OC)OC)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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