SCH 50911 hydrochloride is a selective, orally-active antagonist of the γ-Aminobutyric acid B (GABA(B)) receptor, exhibiting competitive binding with an IC50 value of 1.1 μM. This compound effectively antagonizes GABA(B) autoreceptors, leading to an increase in electrically-stimulated 3H overflow at an IC50 of 3 μM. SCH 50911 hydrochloride is utilized in research applications related to neuropharmacology, particularly in studying the modulation of synaptic transmission and the role of GABA(B) receptors in various neurological disorders.
SCH 50911 hydrochloride is a selective, orally-active antagonist of the γ-Aminobutyric acid B (GABA(B)) receptor, exhibiting competitive binding with an IC50 value of 1.1 μM. This compound effectively antagonizes GABA(B) autoreceptors, leading to an increase in electrically-stimulated 3H overflow at an IC50 of 3 μM. SCH 50911 hydrochloride is utilized in research applications related to neuropharmacology, particularly in studying the modulation of synaptic transmission and the role of GABA(B) receptors in various neurological disorders.
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