SCH 900776 (MK-8776)

Catalog No.: A11167

Chk1 inhibitor

SCH 900776 (MK-8776)

SCH 900776 (MK-8776) Chemical Structure

CAS NO. 891494-63-6

SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
50 mg
$450.00
100 mg
$750.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Min Wu, .et al. FLT3/ITD Cooperates With Rac1 To Modulate The Sensitivity Of Leukemic Cells To Chemotherapeutic Agents Via Regulation Of DNA Repair Pathways, Haematologica, 2019, 104
  • Permata TBM, .et al. Base excision repair regulates PD-L1 expression in cancer cells, Oncogene, 2019, Feb 12 PMID: 30755733
  • Hiro Sato, .et al. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells, Nat Commun, 2017, 8: 1751 PMID: 29170499

Biological Activity

SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

In vitro (25°C) DMSO 3 mg/mL (7.97 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% propylene glycol 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.58 mL 132.89 mL 265.78 mL
0.5 mM 5.32 mL 26.58 mL 53.16 mL
1 mM 2.66 mL 13.29 mL 26.58 mL
5 mM 0.53 mL 2.66 mL 5.32 mL

*The above data is based on the productmolecular weight 376.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11167
Actions Inhibitor
CAS No. 891494-63-6
Formula C15H18BrN7
M. Wt 376.25
Solubility DMSO
Purity >98%
Synonyms SCH-900776, MK-8776, MK8776, MK 8776
SMILES NC1=C(Br)C([[email protected]]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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