SD-436

Name: SD-436
Brand: Adooq Bioscience
SKU: A36514
Rating: 5 (288 reviews)

Catalog No.: A36514

STAT3 PROTAC Degrader

SD-436 is a selective and potent degrader of STAT3, functioning through the PROTAC mechanism with a DC50 of 0.5 μM and an IC50 of 19 nM for STAT3. It promotes the ubiquitination and subsequent degradation of STAT3, leading to significant tumor regression. This reagent is applicable in cancer research, including studies focused on leukemia and lymphoma.

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SD-436 2497585-50-7 STAT3 PROTAC Degrader

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Grouped product items
Size	Price	Stock
1mg	$210.00	In stock
5mg	$645.00	In stock
10mg	$1,060.00	In stock
25mg	$1,980.00	In stock
50mg	$2,885.00	In stock
100mg	$4,960.00	In stock
Bulk Size	Bulk Discount

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Data Sheet SDS

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Adooq Products cited in reputable paper

Biological Activity

Description	SD-436 is a selective and potent degrader of STAT3, functioning through the PROTAC mechanism with a DC50 of 0.5 μM and an IC50 of 19 nM for STAT3. It promotes the ubiquitination and subsequent degradation of STAT3, leading to significant tumor regression. This reagent is applicable in cancer research, including studies focused on leukemia and lymphoma.

Product Information

Catalog Num	A36514
Formula	C58H62F4N9O14PS
Molecular Weight	1248.20
CAS Number	2497585-50-7
SMILES	O=C1[C@H](CN(CC[C@@H]2N1[C@@H](CC2)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N3CCC(CC3)CCC#CC4=CC=CC5=C4CN(C5=O)C6CCC(NC6=O)=O)=O)CC7=CC=C(C(F)=C7)F)=O)=O)C(OC)=O)NC(C8=CC9=C(S8)C=CC(C(F)(P(O)(O)=O)F)=C9)=O

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