SEL120-34A is a potent and selective CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains.
SEL120-34A is a potent and selective CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains.
Targets
Target
Value
Product Information
Catalog Num
A17086
Formula
C15H18Br2N4
Molecular Weight
414.145
CAS Number
1609522-33-9
SMILES
CC1=C2C3=C(C(Br)=C1Br)CCCN3C(N4CCNCC4)=N2
Synonyms
SEL 120-34A, SEL-120-34A, SEL12034A, SEL 12034A, SEL-12034A
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro
DMSO
9 mg/mL (19.97 mM)
Water
77 mg/mL (170.88 mM)
Ethanol
Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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