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Biological Activity
SEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.19 mL | 110.96 mL | 221.93 mL |
| 0.5 mM | 4.44 mL | 22.19 mL | 44.39 mL |
| 1 mM | 2.22 mL | 11.1 mL | 22.19 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.44 mL |
*The above data is based on the productmolecular weight 450.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21485 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1609452-30-3 |
| Formula | C15H18Br2N4.HCl |
| M. Wt | 450.6 |
| Purity | >98% |
| SMILES | CC1=C2C3=C(CCCN3C(=N2)N4CCNCC4)C(=C1Br)Br.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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